Shahrekord University of Medical Sciences Journal of Herbmed Pharmacology 2345-5004 10 1 2021 01 01 Antidiabetic activity of tannin fraction of Bridelia ferruginea (Benth) leaf extract on fructose-induced diabetic mice 68 74 10.34172/jhp.2021.06 EN Sabrina Sanvee https://orcid.org/0000-0001-7427-0685 Oudjaniyobi Simalou https://orcid.org/0000-0003-0541-1274 Gneiny Whad Tchani https://orcid.org/0000-0003-0913-7583 Hèzouwè Kagnou https://orcid.org/0000-0002-3216-8823 Batomayena Bakoma https://orcid.org/0000-0002-1991-2523 Kossi Metowogo https://orcid.org/0000-0002-7704-7881 Kokou Agbékonyi Agbodan https://orcid.org/0000-0002-2193-318X Kafui Kpegba https://orcid.org/0000-0002-9627-262X Journal Article 10.34172/jhp.2021.06 2020 07 09 2020 10 02 Introduction: Bridelia ferruginea is a plant known for its antidiabetic properties. However, few studies on leaf extracts have induced anti-hyperglycemic activity on normal mice subjected to carbohydrate overload. The current study was designed to assess the effect of the leaf extracts’ fraction on fructose-induced diabetic mice. Methods: The in vitro ferric-reducing antioxidant power (FRAP) assay were carried out and the condensed tannins quantified. The vanillin-HCl method was used to characterize the condensed tannins. The antidiabetic effect on fructose-induced diabetic mice was evaluated for 28 days using a fructose-enriched fat diet approach. Results: The fraction confirmed the antioxidant activity with a reducing power of 800 μg/mL comparable to ascorbic acid at 200 μg/mL. The condensed tannins were estimated at 79.6 ± 3.4 mg catechin equivalent per gram of sample. Significant decreases in blood sugar levels of 6.25% at the 7th day, 11.04% at the 14th day, 12.61% at the 21th day, and 11.35% at the 28th day were obtained in mice treated with the extract dose of 200 mg/kg of body weight, compared to the positive control group. The decreases of 37.11% of triglycerides and 40.16% of total cholesterol were also obtained. Conclusion: The investigated fraction showed notable antidiabetic activity and might be a good candidate in the treatment of diabetes.