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  Abstract View: 75

Original Article

Anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of Rumex pictus Forssk. growing in Egypt

Nagwa Mohamed Ammar 1 ORCID logo, Lamiaa Taha Abou El-Kassem 1, 2 ORCID logo, Nahla AbdelHamid Ayoub 3, 4 ORCID logo, Sherweit Hamed El-Ahmady 4 ORCID logo, Maysa Elsayed Moharam 5 ORCID logo, Enaam Mohamed AbouZeid 1* ORCID logo

1 Department of Pharmacognosy, National Research Centre, Cairo, Egypt
2 Department of Chemistry, Faculty of Science & Arts, King Abdulaziz University, Rabigh, Saudi Arabia
3 Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
4 Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
5 Department of Microbial Chemistry, National Research Centre, Cairo, Egypt

Abstract

Introduction: Rumex spp. have been used in folk medicine either as food or as medicine for the treatment of several diseases including constipation, fever, inflammation, bacterial and fungal infections. This study aimed to evaluate the anti-inflammatory and antimicrobial activities of the successive extracts of the aerial parts of Rumex pictus Forssk. growing in Egypt, and to identify the chemical constituents in the bioactive extract. Methods: Ether, chloroformic, and 70% methanolic extracts of the aerial parts of R. pictus were assayed for their in vivo anti-inflammatory activity using carrageenan-induced rat hind paw edema method. These extracts were also tested for their in vitro antibacterial and antifungal activities using disc diffusion method. Results: The 70% methanolic extract of R. pictus exhibited significant anti-inflammatory, antibacterial, and anti-candida activities. Thus, fractionation of the bioactive extract was performed which led to the isolation of three anthraquinones, as well as, seven flavonoids. Conclusion: Rumex pictus possesses anti-inflammatory and antimicrobial activities which reinforce its use in ethnomedicine.
Keywords: Rumex pictus, Phenolic compounds, Anti-inflammatory activity, Antimicrobial activity
Rumex pictus showed significant anti-inflammatory and antimicrobial activities thus might be used as a complementary medicinal plant for treating inflammation and infection after further clinical studies.
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Submitted: 09 Jan 2020
Revision: 11 Apr 2020
Accepted: 11 Apr 2020
ePublished: 20 Oct 2020
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