J Herbmed Pharmacol. 2018;7: 200-210.
doi: 10.15171/jhp.2018.32

Scopus ID: 85050287362
  Abstract View: 4732
  PDF Download: 4357


Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs

Naina Mohamed Pakkir Maideen 1* ORCID logo, Rajkapoor Balasubramaniam 2

1 Dubai Health Authority, Dubai, United Arab Emirates
2 Department of Pharmacology, School of Pharmacy, Mekelle University, Ethiopia
*Corresponding Author: *, Email: nmmaideen@dha.gov.ae


Introduction: Sulfonylurea antidiabetics are insulin secretogogues useful in the treatment of type 2 diabetic patients. The probability of adverse drug interactions is high in patients taking sulfonylureas and other drugs including herbal medicines. The present review is aimed to present the herbal drugs having interacting potentials with sulfonylurea antidiabetics.Methods: The databases such as PubMed, Google Scholar, Science Direct, Directory of open access journals (DOAJ) and reference lists were searched using the keywords drug interactions, Sulfonylureas, pharmacodynamic interactions, antidiabetic herbs, pharmacokinetic interactions and CYP2C9.Results: Sulfonylureas are primarily metabolized by CYP2C9 enzyme and the herbs like St. John’s wort and Ginkgo biloba induce CYP2C9-mediated metabolism of sulfonylureas while fruit juices like Pomegranate juice and Pineapple juice inhibit their metabolism. In addition, the antidiabetic herbal supplements such as Bitter melon, Fenugreek, Cinnamon, Gymnema, Ginseng, Ginger, Garlic, Aloe vera, Sesame, Andrographis paniculata and Neem potentiate the hypoglycemic activity of sulfonylureas, pharmacodynamically.Conclusion: Some herbal supplements are capable of interacting pharmacokinetically and pharmacodynamically with sulfonylurea antidiabetics
Keywords: Sulfonylureas, Antidiabetic herbs, Drug Interactions, Pharmacokinetic interactions, Pharmacodynamic Interactions
First Name
Last Name
Email Address
Security code

Abstract View: 4733

Your browser does not support the canvas element.

PDF Download: 4357

Your browser does not support the canvas element.

Submitted: 06 Dec 2017
Revision: 07 Feb 2018
Accepted: 29 Jun 2018
ePublished: 02 Jul 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)