J Herbmed Pharmacol. 2018;7(4):211-219.
doi: 10.15171/jhp.2018.33
  Abstract View: 42
  PDF Download: 46

Review

Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin

Nadia Boroumand 1 ORCiD, Saeed Samarghandian 2, Seyed Isaac Hashemy 3 * ORCiD

1 Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Basic Medical Science, Neyshabur University of Medical Scisnces, Neyshabur, Iran
3 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Turmeric is a widely used spice derived from the rhizomes of Curcuma longa. Having been used as a dietary spice, it has drawn scientists’ attention to the possible medicinal benefits of its active compounds called curcuminoids which consist of curcumin, demethoxycurcumin and bisdemethoxycurcmin. Considering wide range of pharmacological properties that curcumin offers, numerous studies have investigated its potency as a therapeutic agent in various diseases such as autoimmune, cardiovascular, neoplastic, pulmonary, neurodegenerative and metabolic diseases. With regard to its wide array of health benefits and published data on the underlying mechanisms of its action, a complex interaction between three main events including inflammation, oxidative stress, and immunity, seems to contribute to different therapeutic roles of this compound. Hence, this review discusses the current knowledge on the anti-inflammatory, antioxidant, and immunomodulatory roles of curcumin with the hope of recruiting curcumin as a therapeutic agent in future therapeutic regimen in order to enhance the efficacy of the treatment, as well as decreasing the adverse effects of synthetic chemical drugs.
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Submitted: 07 Mar 2018
Revised: 11 May 2018
Accepted: 06 Oct 2018
First published online: 06 Oct 2018
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